Enantioselective Liquid–Liquid Extraction of Zopiclone With Mandelic Acid Ester Derivatives. Issue 12 (30th September 2013)

• Record Type: Journal Article
• Authors: Peng, Yangfeng; He, Quan; Zuo, Bin; Niu, Haibo; Tong, Tianzhong; Zhao, Hongliang
• Is Part Of: Chirality. Volume 25:Issue 12(2013:Dec.)
• Page Start: 952
• Page End: 956
• Publication Date: 2013-09-30
• Subjects: Chirality -- Periodicals; Pharmaceutical chemistry -- Periodicals; 541.22
• DOI: 10.1002/chir.22239
• Languages: English
• ISSNs: 0899-0042

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p> <named-content id="d591e574" content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">Enantioselective</named-content> liquid–liquid extraction of zopiclone was conducted by employing a series of <italic>(R)</italic>‐mandelic acid esters as chiral extractants. The effects of concentration of extractant, concentration of zopiclone, type of organic solvent, pH value, and temperature on the extraction efficiency were investigated. <italic>(R)‐o</italic>‐chloromandelic acid propyl ester was demonstrated to be an efficient chiral extractant for zopiclone resolution with a maximum <named-content id="d591e597" content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">enantioselectivity</named-content> of 1.6. <italic>Chirality 25:952–956, 2013</italic>. © 2013 Wiley Periodicals, Inc.</p> </abstract>