Enantioselective Determination of the Insecticide Indoxacarb in Cucumber and Tomato by Chiral Liquid Chromatography–Tandem Mass Spectrometry. Issue 6 (28th May 2013)

• Record Type: Journal Article
• Authors: Wang, Huanqing; Dong, Fengshou; Li, Yuanbo; Chen, Xiu; Cheng, Youpu; Xiang, Wensheng; Zheng, Yongquan
• Is Part Of: Chirality. Volume 25:Issue 6(2013:Jun.)
• Page Start: 350
• Page End: 354
• Publication Date: 2013-05-28
• Subjects: Chirality -- Periodicals; Pharmaceutical chemistry -- Periodicals; 541.22
• DOI: 10.1002/chir.22165
• Languages: English
• ISSNs: 0899-0042

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>A convenient and precise chiral method was developed and validated for measuring indoxacarb enantiomers in cucumber and tomato using liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) with a reversed‐phase Chiralpak AD‐RH column. The target analytes were extracted by acetonitrile and then purified by solid phase extraction (SPE) using NH₂/Carb combined‐cartridge. Parameters including the matrix effect, linearity, precision, accuracy, and stability were used. Then the proposed method was successfully applied to investigate the possible enantioselective degradation of <italic>rac</italic>‐indoxacarb in cucumber and tomato under open conditions. The results indicated that the degradation of indoxacarb enantiomers followed first‐order kinetics in cucumber and tomato. The half‐lives of (+)‐<italic>S</italic>‐indoxacarb in cucumber and tomato were 3.0 and 5.9 days, respectively; while the (–)‐<italic>R</italic>‐indoxacarb were 7.3 and 12.2 days, respectively. The data of the half‐lives showed that (+)‐<italic>S</italic>‐indoxacarb was preferentially degraded in cucumber and tomato. Moreover, indoxacarb degraded faster in cucumber than in tomato. Chirality 25:350–354:, 2013. © 2013 Wiley Periodicals, Inc.</p> </abstract>