Rhodium‐Catalyzed Asymmetric Hydroformylation of 1, 1‐Disubstituted Allylphthalimides: A Catalytic Route to β3‐Amino Acids. Issue 4 (22nd February 2013)

• Record Type: Journal Article
• Authors: Zheng, Xin; Cao, Bonan; Liu, Tang‐lin; Zhang, Xumu
• Is Part Of: Advanced synthesis & catalysis. Volume 355:Issue 4(2013)
• Page Start: 679
• Page End: 684
• Publication Date: 2013-02-22
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201200960
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The high enantioselective rhodium‐catalyzed hydroformylation of 1, 1‐disubstituted allylphthalimides has been developed. By employing chiral ligand 1, 2‐bis[(2<italic>S</italic>, 5<italic>S</italic>)‐2, 5‐diphenylphospholano]ethane [(<italic>S</italic>, <italic>S</italic>)‐Ph‐BPE], a series of β³‐aminoaldehydes can be prepared with up to 95% enantioselectivity. This asymmetric procedure provides an efficient alternative route to prepare chiral β³‐amino acids and alcohols.</p> </abstract>