Multifunctional "Click" Prolinamides: A New Platform for Asymmetric Aldol Reactions in the Presence of Water with Catalyst Recycling. Issue 2 (25th January 2013)

• Record Type: Journal Article
• Authors: Paladhi, Sushovan; Das, Joydeb; Mishra, Pratyush Kumar; Dash, Jyotirmayee
• Is Part Of: Advanced synthesis & catalysis. Volume 355:Issue 2/3(2013)
• Page Start: 274
• Page End: 280
• Publication Date: 2013-01-25
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201200856
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>"Click" chemistry is combined with organocatalysis to fabricate a multifunctional <italic>C</italic>₃‐symmetrical dendritic prolinamide with a hydrophobic aromatic core and hydrophilic triazolinium arms that exhibit high efficiency in catalyzing the asymmetric aldol reaction with cyclic ketones. The catalyst is water‐compatible and remains active for five consecutive catalytic runs with a low catalyst loading (2 mol%), yielding the aldol products in high yields, diastereo‐ and enantioselectivities.</p> </abstract>