Aerobic Dehydrogenative Heck Reactions of Heterocycles with Styrenes: A Negative Effect of Metallic Co‐Oxidants. Issue 1 (23rd December 2012)

• Record Type: Journal Article
• Authors: Vasseur, Alexandre; Harakat, Dominique; Muzart, Jacques; Le Bras, Jean
• Is Part Of: Advanced synthesis & catalysis. Volume 355:Issue 1(2013)
• Page Start: 59
• Page End: 67
• Publication Date: 2012-12-23
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201200787
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The aerobic <italic>dehydrogenative Heck reaction</italic> (DHR) of heterocycles with styrenes was found to be more efficient in the absence of metallic co‐oxidants. According to a study of the isotope effect, the CH cleavage was the rate‐determining step of the catalytic cycle. Electrospray ionization mass spectrometry, subsequent MS/MS, and high‐resolution mass spectrometry were used to detect and characterize catalytic intermediates and species formed in the presence of metallic co‐oxidants.</p> </abstract>