Synthesis of Chiral Amino Acid Anilides by Ligand‐Free Copper‐Catalyzed Selective N‐Arylation of Amino Acid Amides. Issue 4 (22nd February 2013)

• Record Type: Journal Article
• Authors: Dong, Junyu; Wang, Yan; Xiang, Qinjie; Lv, Xirui; Weng, Wen; Zeng, Qingle
• Is Part Of: Advanced synthesis & catalysis. Volume 355:Issue 4(2013)
• Page Start: 692
• Page End: 696
• Publication Date: 2013-02-22
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201200752
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>An atom‐economic, practical and cost‐effective protocol for synthesis of chiral amino acid anilides <italic>via</italic> ligand‐free copper‐catalyzed selective CN cross coupling of chiral amino acid amides and aryl halides, hetereoaryl halides and a vinyl bromide has been developed. No racemization occurred during the CN coupling. A plausible mechanism is proposed.</p> </abstract>