Cationic Gold‐ and Silver‐Catalyzed Cycloisomerizations of Propargylic Ureas: A Selective Entry to Oxazolidin‐2‐imines and Imidazolidin‐2‐ones. Issue 4 (25th February 2013)

• Record Type: Journal Article
• Authors: Pereshivko, Olga P.; Peshkov, Vsevolod A.; Jacobs, Jeroen; Meervelt, Luc Van; Van der Eycken, Erik V.
• Is Part Of: Advanced synthesis & catalysis. Volume 355:Issue 4(2013)
• Page Start: 781
• Page End: 789
• Publication Date: 2013-02-25
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201200905
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A comparative study on transition metal‐catalyzed cycloisomerizations of propargylic ureas derived <italic>in situ</italic> from secondary propargylic amines and tosyl isocyanate was performed. The influence of catalytic system on the reaction outcome was thoroughly studied on two model examples resulting in the establishment of two selective protocols for both <italic>O</italic>‐ and <italic>N</italic>‐cyclizations. The application of cationic gold(I) catalysis generally resulted in a formation of oxazolidin‐2‐imines as major products while the application of silver(I) triflate selectively provided the corresponding imidazolidin‐2‐ones. An attempt to rationalize the observed chemoselectivity is described. The scope of both processes was demonstrated through the use of variously substituted secondary propargylic amines.</p> </abstract>