Copper(I)‐Catalyzed [3+2] Cycloaddition/Ring‐Opening Rearrangement/[4+2] Cycloaddition/Aromatization Cascade: An Unprecedented Chemo‐ and Stereoselective Three Component Coupling of Sulfonyl Azide, Alkyne and N‐Arylidenepyridin‐2‐ amine to Pyrido[1, 2‐a]pyrimidin‐4‐imine. Issue 1 (23rd December 2012)

• Record Type: Journal Article
• Authors: Namitharan, Kayambu; Pitchumani, Kasi
• Is Part Of: Advanced synthesis & catalysis. Volume 355:Issue 1(2013)
• Page Start: 93
• Page End: 98
• Publication Date: 2012-12-23
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201200654
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A novel synthetic protocol for the one‐pot chemo‐ and stereoselective construction of diversely functionalized pyrido[1, 2‐<italic>a</italic>]pyrimidin‐4‐imines <italic>via</italic> copper(I)‐catalyzed [3+2] cycloaddition/ring‐opening rearrangement/[4+2] cycloaddition/aromatization cascade of sulfonyl azides, alkynes and <italic>N</italic>‐arylidenepyridin‐2‐amines under mild reaction conditions is reported. In addition, the catalytic activity of copper(I)‐modified zeolite, a recyclable, heterogeneous catalyst is also investigated, which gives improved yield compared to its homogeneous equivalents.</p> </abstract>