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ChemInform Abstract: Enantioselective Synthesis of (+)‐(S)‐7, 8‐Dihydrokavain and (4R, 6R)‐4‐Hydroxy‐6‐(2‐phenylethyl)tetrahydro‐2H‐pyran‐2‐one, Lactone Analogue of Compactin and Mevinolin. Issue 45 (14th October 2013)
Record Type:
Journal Article
Title:
ChemInform Abstract: Enantioselective Synthesis of (+)‐(S)‐7, 8‐Dihydrokavain and (4R, 6R)‐4‐Hydroxy‐6‐(2‐phenylethyl)tetrahydro‐2H‐pyran‐2‐one, Lactone Analogue of Compactin and Mevinolin. Issue 45 (14th October 2013)
Main Title:
ChemInform Abstract: Enantioselective Synthesis of (+)‐(S)‐7, 8‐Dihydrokavain and (4R, 6R)‐4‐Hydroxy‐6‐(2‐phenylethyl)tetrahydro‐2H‐pyran‐2‐one, Lactone Analogue of Compactin and Mevinolin.
<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Simple and efficient synthesis of (+)‐(S)‐7, 8‐dihydrokavain (I) and (4R, 6R)‐4‐hydroxy‐6‐(2‐phenylethyl)tetrahydro‐2H‐pyran‐2‐one (II) is performed, involving Keck allylation and Binol as catalyst in the key stage of building up the carbon scaffold of the target molecule.</p> </abstract>