ChemInform Abstract: Hydrogen‐Bond‐Directed Enantioselective Decarboxylative Mannich Reaction of β‐Ketoacids with Ketimines: Application to the Synthesis of anti‐HIV Drug DPC 083. Issue 35 (8th August 2013) - Yuan, Hai‐Na
Abstract This is the first hydrogen‐bond‐directed enantioselective decarboxylative Mannich reaction of β‐ketoacids with ketimines affording quinazolinone derivatives with quaternary stereocenters in high yields and with excellent enantioselectivities using saccharide‐based amino‐thiourea organocatalysts.