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ChemInform Abstract: Total Synthesis of Bicyclic Depsipeptides Spiruchostatins C and D and Investigation of Their Histone Deacetylase Inhibitory and Antiproliferative Activities. Issue 27 (13th June 2013)
Record Type:
Journal Article
Title:
ChemInform Abstract: Total Synthesis of Bicyclic Depsipeptides Spiruchostatins C and D and Investigation of Their Histone Deacetylase Inhibitory and Antiproliferative Activities. Issue 27 (13th June 2013)
Main Title:
ChemInform Abstract: Total Synthesis of Bicyclic Depsipeptides Spiruchostatins C and D and Investigation of Their Histone Deacetylase Inhibitory and Antiproliferative Activities.
<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Spiruchostatins C (Ia) and D (Ib) possess extremely potent inhibitory activities against cyclic depsipeptide histone deacetylase 1, better than previously known spiruchostatins A and B and the clinically approved depsipeptide FK228.</p> </abstract>