Nanoparticles Mimicking Viral Surface Topography for Enhanced Cellular Delivery. (15th August 2013)

• Record Type: Journal Article
• Authors: Niu, Yuting; Yu, Meihua; Hartono, Sandy B.; Yang, Jie; Xu, Hongyi; Zhang, Hongwei; Zhang, Jun; Zou, Jin; Dexter, Annette; Gu, Wenyi; Yu, Chengzhong
• Is Part Of: Advanced materials. Volume 25:Number 43(2013)
• Page Start: 6233
• Page End: 6237
• Publication Date: 2013-08-15
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201302737
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adma201302737-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Novel silica nanoparticles mimicking virus surface topography</bold> are prepared. It is demonstrated that increases in nanoscale surface roughness promote both binding of biomolecules and cellular uptake; thus, the cellular delivery efficiency is significantly increased (scale bars 20 μm). <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg3x9146b0" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>