Fluorescent Nanoparticle Delivered dsRNA Toward Genetic Control of Insect Pests. (24th June 2013)

• Record Type: Journal Article
• Authors: He, Bicheng; Chu, Yuan; Yin, Meizhen; Müllen, Klaus; An, Chunju; Shen, Jie
• Is Part Of: Advanced materials. Volume 25:Number 33(2013)
• Page Start: 4580
• Page End: 4584
• Publication Date: 2013-06-24
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201301201
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A fluorescent cationic core‐shell nanoparticle</bold> efficiently enters into cells with high transfection efficacy. A FNP/CHT10‐dsRNA complex is orally fed to insect pests and knocks down a midgut‐specific chitinase gene of the Asian corn borer, which leads to death. This is the first report on the genetic control of insect pests through a non‐viral gene delivery system to knock down key developmental gene expression. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg36gzqs9n" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>