Highly Enantioselective Intermolecular Hydroamination of Allylic Amines with Chiral Aldehydes as Tethering Catalysts. Issue 8 (10th January 2013)

• Record Type: Journal Article
• Authors: MacDonald, Melissa J.; Hesp, Colin R.; Schipper, Derek J.; Pesant, Marc; Beauchemin, André M.
• Is Part Of: Chemistry. Volume 19:Issue 8(2013)
• Page Start: 2597
• Page End: 2601
• Publication Date: 2013-01-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201203462
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Chirally LinkedIn</bold>: Chiral aldehydes are effective tethering catalysts for enantioselective intermolecular hydroamination, which provides access to vicinal diamine motifs in good yields and excellent enantioselectivities (see scheme). This work highlights simple chiral α‐oxygenated aldehydes as effective organocatalysts capable of efficiently inducing asymmetry through transient intramolecularity.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1tsnvpqg" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>