Palladium‐Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids to Heterocyclic Acceptors. Issue 1 (3rd December 2012)

• Record Type: Journal Article
• Authors: Holder, Jeffrey C.; Marziale, Alexander N.; Gatti, Michele; Mao, Bin; Stoltz, Brian M.
• Is Part Of: Chemistry. Volume 19:Issue 1(2013)
• Page Start: 74
• Page End: 77
• Publication Date: 2012-12-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201203643
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Flava Flavanone</bold>: Asymmetric conjugate additions to chromones and 4‐quinolones are reported utilizing a single catalyst system formed in situ from Pd(OCOCF₃)₂ and (<italic>S</italic>)‐<italic>t</italic>BuPyOX. Notably, these reactions are performed in wet solvent under ambient atmosphere, and employ readily available arylboronic acids as the nucleophile, thus providing ready access to these asymmetric heterocycles (see scheme).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1p94mn8c" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>