Parahydrogen‐Induced Polarization Transfer to 19F in Perfluorocarbons for 19F NMR Spectroscopy and MRI1. Issue 20 (22nd March 2013)

• Record Type: Journal Article
• Authors: Plaumann, Markus; Bommerich, Ute; Trantzschel, Thomas; Lego, Denise; Dillenberger, Sonja; Sauer, Grit; Bargon, Joachim; Buntkowsky, Gerd; Bernarding, Johannes
• Is Part Of: Chemistry. Volume 19:Issue 20(2013)
• Page Start: 6334
• Page End: 6339
• Publication Date: 2013-03-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201203455
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Fluorinated substances are important in chemistry, industry, and the life sciences. In a new approach, parahydrogen‐induced polarization (PHIP) is applied to enhance ¹⁹F MR signals of (perfluoro‐<italic>n</italic>‐hexyl)ethene and (perfluoro‐<italic>n</italic>‐hexyl)ethane. Unexpectedly, the end‐standing CF₃ group exhibits the highest amount of polarization despite the negligible coupling to the added protons. To clarify this non‐intuitive distribution of polarization, signal enhancements in deuterated chloroform and acetone were compared and ¹⁹F–¹⁹F NOESY spectra, as well as ¹⁹F <italic>T</italic>₁ values were measured by NMR spectroscopy. By using the well separated and enhanced signal of the CF₃ group, first ¹⁹F MR images of hyperpolarized linear semifluorinated alkenes were recorded.</p> </abstract>