Exploiting Aggregation To Achieve Phase Separation in Macrocyclization. Issue 6 (28th December 2012)

• Record Type: Journal Article
• Authors: Bédard, Anne‐Catherine; Collins, Shawn K.
• Is Part Of: Chemistry. Volume 19:Issue 6(2013)
• Page Start: 2108
• Page End: 2113
• Publication Date: 2012-12-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201203433
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The aggregation properties of poly(ethylene glycol) (PEG) can be exploited in organic synthesis to control dilution effects. Through the use of solvent mixtures containing PEG₄₀₀/MeOH, macrocyclization by Glaser–Hay coupling can be conducted at high concentrations. The origin of the selectivity has been studied by using surface tension measurements, UV spectroscopy, and chemical tagging and demonstrates the dependence of the yield and selectivity on the aggregation of PEG₄₀₀ and its ability to preferentially solubilize organic substrates, resulting in a phase separation from the catalyst system.</p> </abstract>