Targeting Loop Adenines in G‐Quadruplex by a Selective Oxirane. Issue 1 (4th December 2012)

• Record Type: Journal Article
• Authors: Doria, Filippo; Nadai, Matteo; Folini, Marco; Scalabrin, Matteo; Germani, Luca; Sattin, Giovanna; Mella, Mariella; Palumbo, Manlio; Zaffaroni, Nadia; Fabris, Daniele; Freccero, Mauro; Richter, Sara N.
• Is Part Of: Chemistry. Volume 19:Issue 1(2013)
• Page Start: 78
• Page End: 81
• Publication Date: 2012-12-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201203097
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Caught in the oxirane</bold>: Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G‐quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G‐quadruplex and shows selective alkylation of the loop adenines, as illustrated.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1p94mmxb" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>