Micronization of the Pharmaceutically Active Agent Genipin by an Antisolvent Precipitation Process1. Issue 1 (11th December 2012)

• Record Type: Journal Article
• Authors: Zhao, X.; Song, K.; Wang, S.; Zu, Y.; Li, N.; Yu, X.
• Is Part Of: Chemical engineering & technology. Volume 36:Issue 1(2013:Jan.)
• Page Start: 33
• Page End: 42
• Publication Date: 2012-12-11
• Subjects: Chemical engineering -- Periodicals; Chemical processes -- Periodicals; 660.05
• DOI: 10.1002/ceat.201200036
• Languages: English
• ISSNs: 0930-7516

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Due to its low water solubility and slow dissolution rate, genipin was micronized by an antisolvent precipitation process using ethanol as solvent and <italic>n</italic>‐hexane as antisolvent. The effects of various experimental parameters on the mean particle size (MPS) of micronized genipin were investigated. By analysis of variance, only the concentration of the genipin solution has a significant effect on the MPS in genipin micronization. Under the optimum conditions, micronized genipin with an MPS of 1.8 μm was obtained. The micronized genipin was characterized by various methods, e.g., scanning electron microscopy and thermogravimetry. The analysis results indicated that the chemical structure of micronized genipin was not changed, but the crystallinity was reduced. The dissolution rate and solubility of the micronized genipin were 2.08 and 1.64 times that of the raw drug. In addition, the residual amounts of <italic>n</italic>‐hexane and ethanol were less than the International Conference on Harmonization limit for solvents.</p> </abstract>