A Ruthenium Catalyst with Simple Triphenylphosphane for the Enantioselective Hydrogenation of Aromatic Ketones. Issue 8 (8th April 2013)

• Record Type: Journal Article
• Authors: Zhou, Han; Huang, Hanmin
• Is Part Of: ChemCatChem. Volume 5:Issue 8(2013:Aug.)
• Page Start: 2253
• Page End: 2257
• Publication Date: 2013-04-08
• Subjects: Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.201300080
• Languages: English
• ISSNs: 1867-3880

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>An efficient Ru catalyst constructed from simple and commercially available triphenylphosphane and enantiopure (1<italic>S</italic>, 1′<italic>S</italic>)‐1, 1′‐biisoindoline (BIDN) was applied to the asymmetric hydrogenation of aromatic ketones. A range of simple aromatic ketones could be hydrogenated with good to excellent enantioselectivities (up to 95 % <italic>ee</italic>). An appropriate enantioselective transition state was proposed to explain the high enantioselectivity obtained with this catalytic system. This study represents the first example to establish a practical Noyori‐type catalyst with a simple achiral monophosphane for highly enantioselective hydrogenation.</p> </abstract>