Single Operation Stereoselective Synthesis of Aerangis Lactones: Combining Continuous Flow Hydrogenation and Biocatalysts in a Chemoenzymatic Sequence. Issue 3 (4th January 2013)

• Record Type: Journal Article
• Authors: Fink, Michael J.; Schön, Michael; Rudroff, Florian; Schnürch, Michael; Mihovilovic, Marko D.
• Is Part Of: ChemCatChem. Volume 5:Issue 3(2013:Mar.)
• Page Start: 724
• Page End: 727
• Publication Date: 2013-01-04
• Subjects: Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.201200753
• Languages: English
• ISSNs: 1867-3880

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Smart catalysis cuts it short:</bold> Natural (<italic>S, S</italic>)‐<italic>Aerangis</italic> lactone and its epimer are synthesized with excellent optical purity by using in‐line hyphenation of continuous flow reactors and batch biotransformations. Optimization of the reaction steps and engineering of the reactor interfaces leads to a simple and efficient setup, which demonstrates how multistep syntheses can be streamlined into a single‐operation protocol.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg36pz0g31" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>