Ring Expansions Within the Gold‐Catalyzed Cycloisomerization of O‐Tethered 1, 6‐Enynes. Application to the Synthesis of Natural‐Product‐like Macrocycles. Issue 5 (9th November 2012)

• Record Type: Journal Article
• Authors: Simonneau, Antoine; Harrak, Youssef; Jeanne‐Julien, Louis; Lemière, Gilles; Mouriès‐Mansuy, Virginie; Goddard, Jean‐Philippe; Malacria, Max; Fensterbank, Louis
• Is Part Of: ChemCatChem. Volume 5:Issue 5(2013:May)
• Page Start: 1096
• Page End: 1099
• Publication Date: 2012-11-09
• Subjects: Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.201200484
• Languages: English
• ISSNs: 1867-3880

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Goldenyne:</bold> <italic>O</italic>‐tethered 1, 6‐enynes that contain a strained ring at the 3 position can cycloisomerize upon cationic gold(I) catalysis through a ring‐expansion process. A two‐step sequence allows the transformation of the cyclized compounds into ketomacrolactones, which are reminiscent of natural products.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1zt57ktj" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>