Long‐term serial angiographic outcomes after sirolimus‐eluting stent implantation1. Issue 1 (8th November 2012)

• Record Type: Journal Article
• Authors: Ko, Euihong; Nasu, Kenya; Habara, Maoto; Tanaka, Nobuyoshi; Terashima, Mitsuyasu; Kinoshita, Yoshihisa; Tsuchikane, Etsuo; Asakura, Yasushi; Katoh, Osamu; Suzuki, Takahiko
• Is Part Of: Catheterization and cardiovascular interventions. Volume 81:Issue 1(2013:Jan. 01)
• Page Start: E29
• Page End: E35
• Publication Date: 2012-11-08
• Subjects: Heart -- Diseases -- Diagnosis -- Periodicals; Cardiac catheterization -- Periodicals; 616.1207572
• DOI: 10.1002/ccd.24383
• Languages: English
• ISSNs: 1522-1946

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Objective</title> <p>We evaluated, using quantitative coronary angiography, the natural history of change that occurred in target lesions after successful sirolimus‐eluting stent (SES) implantation.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Background</title> <p>Percutaneous coronary intervention with drug‐eluting stents (DES) has significantly reduced the rate of repeated target lesion revascularization. However, early studies have raised concerns regarding the "late catch‐up" phenomenon of DES.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Methods</title> <p>Between June 2004 and March 2007, consecutive 217 patients with 306 lesions without restenosis at early angiographic follow‐up underwent late angiographic follow‐up (early follow‐up: 11.2 ± 2.1 months and late follow‐up: 29.4 ± 5.2 months). Predictors of late catch‐up were identified with univariate and multivariate regression analyses.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Results</title> <p>Although reference vessel diameter did not significantly change during follow‐up [3.15 mm (interquartile range (IQR): 2.81–3.49 mm), 3.12 mm (IQR: 2.79–3.47 mm), and 3.08 mm (IQR: 2.76–3.46 mm) at postprocedure, and early and late angiographic follow‐up, respectively; <italic>P</italic> = 0.2653], late loss (LL) significantly increased during follow‐up [0.05 mm (IQR: 0.00–0.13 mm) and 0.08 mm (IQR: 0.01–0.19 mm) at early and late follow‐up, respectively; <italic>P</italic> < 0.0001]. Univariate analysis showed previous intervention, adjunctive use of cutting balloon, lesion length, and progression of MLD, LL, %DS at early follow‐up as predictors of late catch‐up. Multivariate regression analysis identified %DS at early follow‐up as a predictor of late catch‐up (OR 1.076, CI 1.039–1.114, <italic>P</italic> < 0.0001).</p> </sec> <sec id="abs1-5" sec-type="section"> <title>Conclusion</title> <p>Significant and continuous progression of neointima after SES implantation was observed in the present study. Larger LL may be a sign of late catch‐up phenomenon. © 2012 Wiley Periodicals, Inc.</p> </sec> </abstract>