Cover Picture: The Crosslink Formation of 2′‐OMe Oligonucleotide Containing 2‐Amino‐6‐vinylpurine Protects mRNA from miRNA‐Mediated Silencing (ChemBioChem 12/2013). Issue 12 (14th August 2013)

• Record Type: Journal Article
• Authors: Hagihara, Shinya; Lin, Wei‐Chen; Kusano, Shuhei; Chao, Xiao‐guang; Hori, Tsuneaki; Imoto, Shuhei; Nagatsugi, Fumi
• Is Part Of: Chembiochem. Volume 14:Issue 12(2013)
• Page Start: 1389
• Page End: 1389
• Publication Date: 2013-08-14
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201390042
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The cover picture shows</bold> mRNA protected from miRNA‐mediated silencing by a crosslink‐forming oligonucleotide (CFO). The miRNA forms an RNA‐induced silencing complex, and binds to its complementary sequence on target mRNAs. <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">On p. 1427 ff.</ext-link>, F. Nagatsugi et al. describe how the covalent linkage of the CFO to the miRNA biding region can definitely protect the mRNA from miRNA functions. This method can interfere with specific miRNA–mRNA interactions by recognizing the sequences unique to the 3′‐UTR that are inherent in each mRNA.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg36pqvt2k" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>