Visualization of coronary plaque in arterial remodeling using a new 40‐MHz intravascular ultrasound imaging system. Issue 3 (15th March 2012)

• Record Type: Journal Article
• Authors: Araki, Tadashi; Nakamura, Masato; Utsunomiya, Makoto; Sugi, Kaoru
• Is Part Of: Catheterization and cardiovascular interventions. Volume 81:Issue 3(2013:Feb. 15)
• Page Start: 471
• Page End: 480
• Publication Date: 2012-03-15
• Subjects: Heart -- Diseases -- Diagnosis -- Periodicals; Cardiac catheterization -- Periodicals; 616.1207572
• DOI: 10.1002/ccd.23501
• Languages: English
• ISSNs: 1522-1946

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ccd23501-sec-0001" sec-type="section"> <title>Objectives</title> <p>The aim of this study was to characterize coronary plaque in target lesions with vessel remodeling using iMap‐intravascular ultrasound (IVUS).</p> </sec> <sec id="ccd23501-sec-0002" sec-type="section"> <title>Background</title> <p>The relationship between the plaque component and vessel remodeling remains to be elucidated. iMAP‐IVUS is an imaging system that can be used to assess the plaque composition by radiofrequency signals from 40 MHz IVUS.</p> </sec> <sec id="ccd23501-sec-0003" sec-type="section"> <title>Methods</title> <p>IVUS examinations were performed for the de novo target vessels of 146 stable angina pectoris patients (174 vessels). The patients were divided into two groups: including a nonpositive remodeling group (non‐PR, remodeling index ≤ 1.0, 125 vessels) and a positive remodeling group (PR, remodeling index > 1.0, 49 vessels).</p> </sec> <sec id="ccd23501-sec-0004" sec-type="section"> <title>Results</title> <p>The percent plaque burden in the PR group were lager than those in the non‐PR group (79.05% vs. 74.36%, <italic>P</italic> < 0.01). Attenuation plaques were more frequently observed in PR group (40.8% vs. 12.1%, <italic>P</italic> < 0.0001). The percentages of lipidic and necrotic relative areas at the minimum lumen sites were greater in the PR group than in the non‐PR group (7.22% vs. 6.03%, <italic>P</italic> <0.05 and 22.08% vs. 14.71%, <italic>P</italic> < 0.001, respectively), and the percentage of the fibrotic area was smaller (54.82% vs. 61.42%, P < 0.05). In addition, a positive linear correlation was observed between the remodeling index and either the lipidic or necrotic area (<italic>r</italic> = 0.37, <italic>P</italic> <0.0001 and <italic>r</italic> = 0.35, <italic>P</italic> < 0.0001, respectively).</p> </sec> <sec id="ccd23501-sec-0005" sec-type="section"> <title>Conclusions</title> <p>The coronary plaque characteristics in PR patients showed increased lipidic and necrotic areas and the degree of coronary remodeling correlated with the lipidic and necrotic plaque area. © 2012 Wiley Periodicals, Inc.</p> </sec> </abstract>