Characterisation of CMP‐Sialic Acid Transporter Substrate Recognition. Issue 15 (6th September 2013)

• Record Type: Journal Article
• Authors: Maggioni, Andrea; von Itzstein, Mark; Rodríguez Guzmán, Ingrid Bibiana; Ashikov, Angel; Stephens, Alexandre S.; Haselhorst, Thomas; Tiralongo, Joe
• Is Part Of: Chembiochem. Volume 14:Issue 15(2013)
• Page Start: 1936
• Page End: 1942
• Publication Date: 2013-09-06
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201300298
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>CMP‐sialic acid transporter:</bold> We report an in‐depth, multidisciplinary, structural study that has identified the amino acid residues intimately involved in CMP‐sialic acid transporter (CST) substrate specificity. Our data provide a significant contribution towards a better understanding the structure–function relationship of this important family of transporters and the rational design of CST inhibitors.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg3jxw6ckw" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>