The Crosslink Formation of 2′‐OMe Oligonucleotide Containing 2‐Amino‐6‐vinylpurine Protects mRNA from miRNA‐Mediated Silencing. Issue 12 (24th July 2013)

• Record Type: Journal Article
• Authors: Hagihara, Shinya; Lin, Wei‐Chen; Kusano, Shuhei; Chao, Xiao‐guang; Hori, Tsuneaki; Imoto, Shuhei; Nagatsugi, Fumi
• Is Part Of: Chembiochem. Volume 14:Issue 12(2013)
• Page Start: 1427
• Page End: 1429
• Publication Date: 2013-07-24
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201300382
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Masking the miRNA binding site:</bold> Crosslink‐forming oligonucleotide (CFO) was used for target gene‐specific inhibition of microRNA (miRNA) functions. This method can interfere with specific miRNA–mRNA interactions by recognizing sequences unique to the 3′‐UTR that are inherent in each mRNA.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg36pqvxc3" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>