Cover Picture: The Protein Corona Mediates the Impact of Nanomaterials and Slows Amyloid Beta Fibrillation (ChemBioChem 5/2013). Issue 5 (11th March 2013)

• Record Type: Journal Article
• Authors: Mahmoudi, Morteza; Monopoli, Marco P.; Rezaei, Meisam; Lynch, Iseult; Bertoli, Filippo; McManus, Jennifer J.; Dawson, Kenneth A.
• Is Part Of: Chembiochem. Volume 14:Issue 5(2013)
• Page Start: 525
• Page End: 525
• Publication Date: 2013-03-11
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201390012
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The cover picture shows</bold> that the presence of the protein corona at the surface of nanomaterials inhibits the fibrillation process of amyloid beta (Aβ) monomers. Several different nanomaterials [i.e., silica (100 and 200 nm), polystyrene with carboxyl surface modification (100 nm), and multi‐walled carbon nanotubes (10–40 nm in diameter and 0.1–10 mm in length)] were used, and their effects on the Aβ fibrillation process were probed in the absence and presence of a protein corona, as well as well as under conditions under whic the protein corona was denatured. In their communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">p. 568 ff.</ext-link>, M. Mahmoudi, J. J. McManus, K. A. Dawson, et al. show that the protein corona creates a shell at the surface of nanomaterials, regardless of their physico‐chemical properties (e.g., size, core composition, shape, and surface properties), that reduces the levels of Aβ fibril formation.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1v91xb3v" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>