A Polymer–(Tandem Drugs) Conjugate for Enhanced Cancer Treatment. Issue 6 (7th January 2013)

• Record Type: Journal Article
• Authors: Zhou, Dongfang; Xiao, Haihua; Meng, Fanbo; Li, Xiaoyuan; Li, Yuxin; Jing, Xiabin; Huang, Yubin
• Is Part Of: Advanced healthcare materials. Volume 2:Issue 6(2013:Jun.)
• Page Start: 822
• Page End: 827
• Publication Date: 2013-01-07
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201200385
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A novel strategy for combination chemotherapy (platinum and demethylcantharidin) via a polymer–(tandem drugs) conjugate</bold> for enhanced cancer treatment is demonstrated. Cisplatin can be released inside cell by reduction to attack DNA, while DMC will be hydrolyzed subsequently to block DNA‐damage‐induced defense mechanisms by serine/threonine phosphatase PP2A inhibition. Synergistic effect of the polymer–(tandem drugs) conjugate causes complete suppression of H22 liver tumor xenografts without recurrence. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg223x9csh" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>