Chitosan Electrodeposition for Microrobotic Drug Delivery. Issue 7 (25th January 2013)

• Record Type: Journal Article
• Authors: Fusco, Stefano; Chatzipirpiridis, George; Sivaraman, Kartik M.; Ergeneman, Olgaç; Nelson, Bradley J.; Pané, Salvador
• Is Part Of: Advanced healthcare materials. Volume 2:Issue 7(2013:Jul.)
• Page Start: 1037
• Page End: 1044
• Publication Date: 2013-01-25
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201200409
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A method to functionalize steerable magnetic microdevices through the co‐electrodeposition of drug loaded chitosan hydrogels is presented. The characteristics of the polymer matrix have been investigated in terms of fabrication, morphology, drug release and response to different environmental conditions. Modifications of the matrix behavior could be achieved by simple chemical post processing. The system is able to load and deliver 40–80 μg cm⁻² of a model drug (Brilliant Green) in a sustained manner with different profiles. Chitosan allows a pH responsive behavior with faster and more efficient release under slightly acidic conditions as can be present in tumor or inflamed tissue. A prototype of a microrobot functionalized with the hydrogel is presented and proposed for the treatment of posterior eye diseases.</p> </abstract>