One‐Step Photo Synthesis of Protein–Drug Nanoassemblies for Drug Delivery. Issue 6 (7th January 2013)

• Record Type: Journal Article
• Authors: Xie, Jinbing; Cao, Yi; Xia, Mao; Gao, Xiang; Qin, Meng; Wei, Jiwu; Wang, Wei
• Is Part Of: Advanced healthcare materials. Volume 2:Issue 6(2013:Jun.)
• Page Start: 795
• Page End: 799
• Publication Date: 2013-01-07
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201200285
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Upon controlled UV illumination, disulfide bonds in bovine α‐lactalbumin (BLA)</bold> are selectively broken, leading to self‐assembly of the BLA and doxorubicin (DOX) molecules into nanoparticles via hydrophobic interactions and intermolecular disulfide bonds. Such protein–drug nanoparticles have synergistic anticancer activity in vitro and tumor‐homing specificity in vivo, which are of great potential for systemic drug delivery in cancer therapy. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg223x9c41" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>