An Enzymatic Route to Selenazolines. Issue 5 (18th February 2013)

• Record Type: Journal Article
• Authors: Koehnke, Jesko; Morawitz, Falk; Bent, Andrew F.; Houssen, Wael E.; Shirran, Sally L.; Fuszard, Matthew A.; Smellie, Iain A.; Botting, Catherine H.; Smith, Margaret C. M.; Jaspars, Marcel; Naismith, James H.
• Is Part Of: Chembiochem. Volume 14:Issue 5(2013)
• Page Start: 564
• Page End: 567
• Publication Date: 2013-02-18
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201300037
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Ringing the changes:</bold> Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1v91xbgx" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>