Rhabdopeptides as Insect‐Specific Virulence Factors from Entomopathogenic Bacteria. Issue 15 (3rd September 2013)

• Record Type: Journal Article
• Authors: Reimer, Daniela; Cowles, Kimberly N.; Proschak, Anna; Nollmann, Friederike I.; Dowling, Andrea J.; Kaiser, Marcel; Constant, Richard ffrench‐; Goodrich‐Blair, Heidi; Bode, Helge B.
• Is Part Of: Chembiochem. Volume 14:Issue 15(2013)
• Page Start: 1991
• Page End: 1997
• Publication Date: 2013-09-03
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201300205
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Six novel linear peptides, named "rhabdopeptides", have been identified in the entomopathogenic bacterium <italic>Xenorhabdus nematophila</italic> after the discovery of the corresponding <italic>rdp</italic> gene cluster by using a promoter trap strategy for the detection of insect‐inducible genes. The structures of these rhabdopeptides were deduced from labeling experiments combined with detailed MS analysis. Detailed analysis of an <italic>rdp</italic> mutant revealed that these compounds participate in virulence towards insects and are produced upon bacterial infection of a suitable insect host. Furthermore, two additional rhabdopeptide derivatives produced by <italic>Xenorhabdus cabanillasii</italic> were isolated, these showed activity against insect hemocytes thereby confirming the virulence of this novel class of compounds.</p> </abstract>