Acetylcholinesterase‐Inhibitory Activities of the Extracts from Sponges Collected in Mauritius Waters. Issue 3 (13th March 2013)

• Record Type: Journal Article
• Authors: Beedessee, Girish; Ramanjooloo, Avin; Surnam‐Boodhun, Rashmee; van Soest, Rob W. M.; Marie, Daniel E. P.
• Is Part Of: Chemistry & biodiversity. Volume 10:Issue 3(2013:Mar.)
• Page Start: 442
• Page End: 451
• Publication Date: 2013-03-13
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201200343
• Languages: English
• ISSNs: 1612-1872

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Patients diagnosed with <italic>Alzheimer</italic>'s disease (AD) show a characteristic neurochemical deficit of acetylcholine, especially in the basal forebrains. The use of acetylcholinesterase (AChE) inhibitors to retard the hydrolysis of acetylcholine has been suggested as a promising strategy for AD treatment. In this study, we evaluated the acetylcholinesterase inhibitory (AChEI) activities of 134 extracts obtained from 45 species of marine sponges. Thin‐layer chromatography (TLC) and microplate assays reveal potent acetylcholinsterase inhibitory activities of two AcOEt extracts from the sponges <italic>Pericharax heteroraphis</italic> and <italic>Amphimedon navalis</italic><sc>Pulitzer‐Finali</sc>. We further investigated the inhibitory kinetics of the extracts and found them to display mixed competitive/noncompetitive inhibition and associated their inhibitory activity partly to terpenoids. Acetylcholinesterase inhibitors from marine organisms have been rarely studied, and this study demonstrated the potential of marine sponges as a source of pharmaceutical leads against neurodegenerative diseases.</p> </abstract>