Ultra‐small, Uniform, and Single bcc‐Phased FexCo1‐x/Graphitic Shell Nanocrystals for T1 Magnetic Resonance Imaging Contrast Agents. Issue 1 (14th November 2012)

• Record Type: Journal Article
• Authors: Choi, In Ae; Li, Yan; Kim, Da Jeong; Pal, Mou; Cho, Jee‐Hyun; Lee, Kyujoon; Jung, Myung‐Hwa; Lee, Chulhyun; Seo, Won Seok
• Is Part Of: Chemistry, an Asian journal. Volume 8:Issue 1(2013:Jan.)
• Page Start: 290
• Page End: 295
• Publication Date: 2012-11-14
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201200950
• Languages: English
• ISSNs: 1861-4728

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>We have synthesized ultra‐small and uniform Fe_xCo_1‐x/graphitic carbon shell (Fe_xCo_1‐x/GC) nanocrystals (x=0.13, 0.36, 0.42, 0.50, 0.56, and 0.62, respectively) with average diameters of &lt;4 nm by thermal decomposition of metal precursors in approximately 60 nm MCM‐41 and methane CVD. The composition of the Fe_xCo_1‐x/GC nanocrystals can be tuned by changing the Fe:Co ratios of the metal precursors. The Fe_xCo_1‐x/GC nanocrystals show superparamagnetic properties at room temperature. The Fe_0.50Co_0.50/GC, Fe_0.56Co_0.44/GC, and Fe_0.62Co_0.38/GC nanocrystals have a single bcc FeCo structure, whereas the Fe_0.13Co_0.87/GC, Fe_0.36Co_0.64/GC, and Fe_0.42Co_0.58/GC nanocrystals have a mixed structure of bcc FeCo and fcc Co. The single bcc‐phased Fe_xCo_1‐x/GC nanocrystals functionalized with phospholipid–poly(ethylene glycol) (PL–PEG) in phosphate buffered saline (PBS) are demonstrated to be excellent <italic>T</italic>₁ MRI contrast agents.</p> </abstract>