Synthesis of Pyrimidones and Evaluation of Their Xanthine Oxidase Inhibitory and Antioxidant Activities. Issue 11 (20th September 2013)

• Record Type: Journal Article
• Authors: Gurupadaswamy, Handuvinahalli Devanna; Girish, Virupaksha; Zameer, Farhan; Hegdekatte, Raghavendra; Chauhan, Jyoti Bala; Khanum, Shaukath Ara
• Is Part Of: Archiv der Pharmazie. Volume 346:Issue 11(2013:Nov.)
• Page Start: 805
• Page End: 811
• Publication Date: 2013-09-20
• Subjects: Pharmaceutical chemistry -- Periodicals; Pharmacology -- Periodicals; 615.19
• DOI: 10.1002/ardp.201300240
• Languages: English
• ISSNs: 0365-6233

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ardp201300240-sec-0001" sec-type="section"> <p>The increasing prevalence of gout has been accompanied by a growing number of patients intolerant to or with disease refractory to the available urate‐lowering therapies. This metabolic disease is a common disease with a higher prevalence in men older than 30 years and in women older than 50 years. These findings highlight the need for emerging treatments to effectively lower urate levels. In this view, we describe the xanthine oxidase (XO) inhibitory activities of the synthesized compounds <bold>5a</bold>–<bold>j</bold> and also their antioxidant activities. Compounds <bold>5c</bold>, <bold>5d</bold>, <bold>5f</bold>, <bold>5h</bold>, and <bold>5j</bold> exhibited good inhibitory activities against XO. On the other hand, compounds <bold>5g</bold> and <bold>5j</bold> exhibited moderate antioxidant activity.</p> </sec> </abstract>