PrPc is temporospatially expressed in molar development of rats. Issue 12 (11th October 2013)
- Record Type:
- Journal Article
- Title:
- PrPc is temporospatially expressed in molar development of rats. Issue 12 (11th October 2013)
- Main Title:
- PrPc is temporospatially expressed in molar development of rats
- Authors:
- Yoo, H.I.
Jang, S.M.
Kang, J.H.
Kim, M.S.
Koh, J.T.
Jung, J.Y.
Kim, W.J.
OH, W.M.
Kim, S.H. - Abstract:
- <abstract abstract-type="main"> <title>ABSTRACT</title> <p>Odontogenesis, tooth development, is derived from two tissue components: ectoderm and neural crest‐derived mesenchyme. Cyto‐differentiation of odontogenic cells during development involves time‐dependent and sequential regulation of genetic programs. This study was conducted to detect molecules implicated in cyto‐differentiation of developing molar germs of rats. Differential display‐PCR revealed that PrP<sup>c</sup> was differentially expressed between cap/early bell‐staged germs (maxillary 3rd molar germs) and root formation‐staged germs (maxillary 2nd molar germs) at postnatal day 9. Both levels of PrP<sup>c</sup> mRNA and protein expression were higher in the root formation stage than the cap/early bell stage and increased in a time‐dependent manner. Immunofluorescence revealed for the first time that PrP<sup>c</sup> was not localized in the enamel organ, but localized in dental follicular cells for the development of the periodontal ligament and cementum as well as odontoblasts, both of which are of neural crest origin. These results suggest that the physiological functions of the PrP<sup>c</sup> in tooth development may be implicated in the differentiation of neural crest‐derived mesenchyme including the periodontal tissues for root formation rather than epithelial tissue. Anat Rec, 296:1929–1935, 2013. © 2013 Wiley Periodicals, Inc.</p> </abstract>
- Is Part Of:
- Anatomical record. Volume 296:Issue 12(2013:Dec.)
- Journal:
- Anatomical record
- Issue:
- Volume 296:Issue 12(2013:Dec.)
- Issue Display:
- Volume 296, Issue 12 (2013)
- Year:
- 2013
- Volume:
- 296
- Issue:
- 12
- Issue Sort Value:
- 2013-0296-0012-0000
- Page Start:
- 1929
- Page End:
- 1935
- Publication Date:
- 2013-10-11
- Subjects:
- Anatomy -- Periodicals
Evolution (Biology) -- Periodicals
Morphology -- Periodicals
571.3 - Journal URLs:
- http://www3.interscience.wiley.com/cgi-bin/jhome/113463905 ↗
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1932-8494 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/ar.22807 ↗
- Languages:
- English
- ISSNs:
- 1932-8486
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0898.005000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 3104.xml