A polyurethane‐based nanocomposite biocompatible bone adhesive. Issue 6 (14th June 2012)

• Record Type: Journal Article
• Authors: Schreader, Kevin J.; Bayer, Ilker S.; Milner, Derek J.; Loth, Eric; Jasiuk, Iwona
• Is Part Of: Journal of applied polymer science. Volume 127:Issue 6(2013:Mar. 15)
• Page Start: 4974
• Page End: 4982
• Publication Date: 2012-06-14
• Subjects: Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.38100
• Languages: English
• ISSNs: 0021-8995

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A novel polyurethane‐based foam‐like adhesive reinforced with nanosized hydroxyapatite (HA) particles was developed and investigated for bone‐to‐bone bonding applications in terms of mechanical adhesion and biocompatibility. The adhesive has a hierarchical structure with HA particles at the nanoscale level and pores at the micro‐scale level. This adhesive was tested mechanically in the three principal loading modes anticipated: shear, tension, and compression. Standard testing procedures were used when available. Tensile strength of primed adhesive showed a four‐fold increase in adhesion on unmodified bone and a nearly two‐fold increase in adhesion to primed bone as compared with the conventional bone cement. Biocompatibility was initially assessed <italic>in vitro</italic> using cell culture tests, which showed positive interaction with the adhesive. Then, a second biocompatibility test was performed using <italic>Xenopus laevis</italic> limbs to assess an <italic>in vivo</italic> response. The results indicated that the adhesive material produces a normal response consistent with control specimens. However, long‐term observations and tests with additional species are needed to demonstrate full biocompatibility. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2013</p> </abstract>