Definitive treatment of androgen receptor–positive salivary duct carcinoma with androgen deprivation therapy and external beam radiotherapy. Issue 1 (17th September 2013)

• Record Type: Journal Article
• Authors: Soper, Margaret S.; Iganej, Shawn; Thompson, Lester D. R.; Andersen, Peter
• Is Part Of: Head & neck. Volume 36:Issue 1(2014:Jan.)
• Page Start: E4
• Page End: E7
• Publication Date: 2013-09-17
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23383
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="hed23383-sec-0001" sec-type="section"> <title>Background</title> <p>Salivary duct carcinoma (SDC) is an aggressive malignancy with high recurrence rates. Standard management includes surgical resection followed by adjuvant radiation. Androgen receptor positivity has been described to be present in 40% to 90% of SDCs, and a recent case series showed a benefit to androgen deprivation therapy (ADT) in recurrent or metastatic disease.</p> </sec> <sec id="hed23383-sec-0002" sec-type="section"> <title>Methods and Results</title> <p>We present the case of an 87‐year‐old woman with a locally advanced androgen receptor–positive parotid SDC treated definitively with ADT and external beam radiotherapy, a regimen modeled after the treatment of prostate cancer. She had a complete response on positron emission tomography (PET)/CT scan and had no evidence of disease 24 months after the completion of treatment.</p> </sec> <sec id="hed23383-sec-0003" sec-type="section"> <title>Conclusion</title> <p>To our knowledge, this case report is the first to describe the use of ADT plus radiation to definitively treat SDC. This regimen could be considered in patients with androgen receptor–positive SDCs who are considered unresectable or who refuse surgery. © 2013 Wiley Periodicals, Inc. <italic>Head Neck</italic><bold>36</bold>: E4–E7, 2014</p> </sec> </abstract>