Convenient Synthesis of a Polyester‐co‐Polyether Block for Assembling Biocompatible Hyperbranched Macromolecules. Issue 2 (29th November 2013)

• Record Type: Journal Article
• Authors: Elkin, Igor; Hildgen, Patrice
• Is Part Of: Macromolecular chemistry and physics. Volume 215:Issue 2(2014:Jan.)
• Page Start: 177
• Page End: 181
• Publication Date: 2013-11-29
• Subjects: Polymers -- Periodicals; Polymerization -- Periodicals; Synthetic products -- Periodicals; Macromolecules -- Periodicals; 547.7
• DOI: 10.1002/macp.201300578
• Languages: English
• ISSNs: 1022-1352

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Synthesis of a novel multifunctional block based on asymmetrically substituted pentaerythritol, succinic acid, and tetraethylene glycol is reported. The proposed reaction conditions allow selective preparation of the product in high overall yield. The block can be used in the assembly of biocompatible polyester‐<italic>co</italic>‐polyether (PEPE) hyperbranched macromolecules, which allows the product to be considered as a promising intermediate for the development of new biomedical dendrimers. As an example, the use of the "block by block" strategy is employed to obtain a second‐generation dendron. It is shown that the approach is much more efficient than the pathway of step‐by‐step grafting of separate molecular fragments. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg40bk3qg5" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>