Aptamer‐conjugated magnetic nanoparticles enable efficient targeted detection of integrin αvβ3 via magnetic resonance imaging. Issue 1 (9th April 2013)

• Record Type: Journal Article
• Authors: Lim, Eun‐Kyung; Kim, Bongjune; Choi, Yuna; Ro, Youngjun; Cho, Eun‐Jin; Lee, Jung Hwan; Ryu, Sung‐Ho; Suh, Jin‐Suck; Haam, Seungjoo; Huh, Yong‐Min
• Is Part Of: Journal of biomedical materials research. Volume 102:Issue 1(2014:Jan.)
• Page Start: 49
• Page End: 59
• Publication Date: 2013-04-09
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.a.34678
• Languages: English
• ISSNs: 1549-3296

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>An understanding of neovascularization and/or angiogenesis in cancer is acutely required for effective cancer therapy due to concerns about tumor growth and metastasis. In particular, integrin αvβ3 is closely associated with cell migration and invasion during angiogenesis. Hence, we developed aptamer_αvβ3‐conjugated magnetic nanoparticles (Apt_αvβ3‐MNPs) to enable precise detection of integrin‐expressing cancer cells using magnetic resonance imaging. Apt_αvβ3‐MNPs exhibited not only cytocompatibility, but also an efficient targeting ability with high magnetic sensitivity through <italic>in vitro</italic>/<italic>in vivo</italic> studies. The results of this study demonstrate that Apt_αvβ3‐MNPs have the potential to be used for accurate tumor diagnosis and therapy. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 49–59, 2014.</p> </abstract>