Comparative effectiveness of drug‐eluting stents on long‐term outcomes in elderly patients treated for in‐stent restenosis: A report from the National Cardiovascular Data Registry. Issue 2 (31st August 2013)

• Record Type: Journal Article
• Authors: Kutcher, Michael A.; Brennan, J. Matthew; Rao, Sunil V.; Dai, David; Anstrom, Kevin J.; Mustafa, Nowwar; Sedrakayan, Art; Booth, Michael E.; Douglas, Pamela S.; Messenger, John C.
• Is Part Of: Catheterization and cardiovascular interventions. Volume 83:Issue 2(2014:Feb. 01)
• Page Start: 171
• Page End: 181
• Publication Date: 2013-08-31
• Subjects: Heart -- Diseases -- Diagnosis -- Periodicals; Cardiac catheterization -- Periodicals; 616.1207572
• DOI: 10.1002/ccd.25108
• Languages: English
• ISSNs: 1522-1946

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ccd25108-sec-0001" sec-type="section"> <title>Objective</title> <p>We assessed the long‐term outcomes of elderly patients who had in‐stent restenosis (ISR) treated with drug‐eluting stents (DES) compared with other treatment strategies.</p> </sec> <sec id="ccd25108-sec-0002" sec-type="section"> <title>Background</title> <p>Elderly patients with ISR represent a vulnerable group of which little is known regarding the safety and efficacy of repeat percutaneous coronary intervention (PCI).</p> </sec> <sec id="ccd25108-sec-0003" sec-type="section"> <title>Methods</title> <p>We analyzed patients ≥65 years of age who underwent PCI for ISR in the National Cardiovascular Data Registry<sup>®</sup> from 2004 to 2008. Death, myocardial infarction (MI), revascularization, stroke, and bleeding were assessed for up to 30 months by a linkage with Medicare rehospitalization claims.</p> </sec> <sec id="ccd25108-sec-0004" sec-type="section"> <title>Results</title> <p>Of 43, 679 linked patients, 30, 012 were treated with DES, 8, 277 with balloon angioplasty (BA), and 4, 917 with bare metal stents (BMS). Compared with BMS, DES use was associated with a lower propensity score‐matched (PM) risk of death (hazard ratio [HR] 0.72; 95% confidence interval [CI] 0.66–0.80, <italic>P</italic> < 0.001), MI (HR 0.81; 95% CI 0.70–0.93, <italic>P</italic> = 0.003), and revascularization (HR 0.90; 95% CI 0.82–1.00, <italic>P</italic> = 0.055). Compared with BA, DES use was associated with a lower PM risk of death (HR 0.82; 95% CI 0.76–0.89, <italic>P</italic> < 0.001) and revascularization (HR 0.86; 95% CI 0.80‐0.93, <italic>P</italic> < 0.001), but no statistically significant difference across other endpoints. There were no significant differences in long‐term outcomes for BA compared with BMS.</p> </sec> <sec id="ccd25108-sec-0005" sec-type="section"> <title>Conclusions</title> <p>There was lower mortality and reduced risk for MI, revascularization, and stroke, but a similar rate of bleeding with DES compared with other modalities. Our results indicate that DES use is a comparatively effective strategy to treat elderly patients with ISR. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>