Interpretative consequences of adopting the global lungs 2012 reference equations for spirometry for children and adolescents. Issue 2 (20th September 2013)

• Record Type: Journal Article
• Authors: Quanjer, Philip H.; Weiner, Daniel J.
• Is Part Of: Pediatric pulmonology. Volume 49:Issue 2(2014:Feb.)
• Page Start: 118
• Page End: 125
• Publication Date: 2013-09-20
• Subjects: Pediatric respiratory diseases -- Periodicals; Pediatrics -- Periodicals; 618.922
• DOI: 10.1002/ppul.22876
• Languages: English
• ISSNs: 8755-6863

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Summary</title> <sec id="ppul22876-sec-0001" sec-type="section"> <title>Objective</title> <p>To determine the interpretative consequences of adopting the Global Lungs 2012 (GLI‐2012) spirometric prediction equations in a pediatric hospital population.</p> </sec> <sec id="ppul22876-sec-0002" sec-type="section"> <title>Material</title> <p>Spirometric records from 2, 192 white boys and 1, 842 white girls, and 412 and 334 African–American boys and girls, respectively, aged 6.0–18.0 years, treated mainly for asthma, cystic fibrosis, cough, and dyspnoea.</p> </sec> <sec id="ppul22876-sec-0003" sec-type="section"> <title>Methods</title> <p>Predicted values and lower limits of normal were calculated for FEV<sub>1</sub>, FVC, and FEV<sub>1</sub>/FVC, using prediction equations from GLI‐2012, Hankinson, Knudson, Polgar, Wang, and Zapletal. Obstruction was defined as FEV<sub>1</sub>/FVC < LLN, a restrictive pattern as FEV<sub>1</sub>/FVC > LLN and FVC < LLN.</p> </sec> <sec id="ppul22876-sec-0004" sec-type="section"> <title>Results</title> <p>There was good agreement for predicted values for FEV<sub>1</sub>, FVC, and FEV<sub>1</sub>/FVC from GLI‐2012, Hankinson and Wang equations within ethnic groups. A near normal FEV<sub>1</sub> but above normal FVC contributed to a low FEV<sub>1</sub>/FVC, particularly in African–Americans. Polgar, Knudson, and Zapletal predicteds produced disparate results. A restrictive pattern occurred in 2.2–11.2% of cases, with no statistical difference between GLI‐2012 and Hankinson.</p> </sec> <sec id="ppul22876-sec-0005" sec-type="section"> <title>Conclusions</title> <p>Transition from Hankinson and Wang equations to GLI‐2012 leads to grossly similar prevalence rates of abnormally low values for FEV<sub>1</sub>, FVC, and FEV<sub>1</sub>/FVC, unlike equations from Knudson, Polgar, and Zapletal. <bold>Pediatr Pulmonol. 2014; 49:118–125.</bold> © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>