Production of 18F‐Labeled Titanium Dioxide Nanoparticles by Proton Irradiation for Biodistribution and Biological Fate Studies in Rats. (4th November 2013)

• Record Type: Journal Article
• Authors: Pérez‐Campaña, Carlos; Sansaloni, Francesc; Gómez‐Vallejo, Vanessa; Baz, Zuriñe; Martin, Abraham; Moya, Sergio E.; Lagares, Juan I.; Ziolo, Ronald F.; Llop, Jordi
• Is Part Of: Particle and particle systems characterization. Volume 31:Number 1(2014:Jan.)
• Page Start: 134
• Page End: 142
• Publication Date: 2013-11-04
• Subjects: Particles -- Periodicals; 620.43
• DOI: 10.1002/ppsc.201300302
• Languages: English
• ISSNs: 0934-0866

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>A simple and straightforward method is presented for the direct proton beam activation of ¹⁸O‐enriched titanium dioxide nanoparticles (TiO₂ NPs) via the ¹⁸O(p, n)¹⁸F nuclear reaction in order to assess the biological fate of the NPs using positron emission tomography (PET). The radiolabeling of the NPs does not alter their morphological properties as demonstrated by transmission electron microscopy and dynamic light scattering measurements. The simultaneous formation of other radioisotopes by activation of the titanium atom, i.e., ⁴⁸V, ⁴⁷V, ^44gSc, has been investigated using high‐resolution gamma spectrometry and PET. The labeling of TiO₂ NPs with radioactive ¹⁸F atoms makes it possible to perform short‐term in vivo biodistribution studies of the metal oxide NPs in rats after intravenous and oral administration using PET. The accumulation of NPs in different organs could be quantified during almost 8 h after administration.</p> </abstract>