Clofarabine salvage therapy in refractory multifocal histiocytic disorders, including Langerhans cell histiocytosis, juvenile xanthogranuloma and Rosai–Dorfman disease. Issue 3 (18th September 2013)

• Record Type: Journal Article
• Authors: Simko, Stephen J.; Tran, Huy D.; Jones, Jeremy; Bilgi, Mrinalini; Beaupin, Lynda Kwon; Coulter, Don; Garrington, Timothy; McCavit, Timothy L.; Moore, Colin; Rivera‐Ortegón, Francisco; Shaffer, Linda; Stork, Linda; Turcotte, Lucie; Welsh, Esperanza C.; Hicks, M. John; McClain, Kenneth L.; Allen, Carl E.
• Is Part Of: Pediatric blood & cancer. Volume 61:Issue 3(2014:Mar.)
• Page Start: 479
• Page End: 487
• Publication Date: 2013-09-18
• Subjects: Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.24772
• Languages: English
• ISSNs: 1545-5009

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="pbc24772-sec-0001" sec-type="section"> <title>Background</title> <p>Existing therapies for recurrent or refractory histiocytoses, including Langerhans cell histiocytosis (LCH), juvenile xanthogranuloma (JXG), and Rosai–Dorfman disease (RDD), have limited effectiveness. We report our experience with using clofarabine as therapy in children with recurrent or refractory histiocytic disorders, including LCH (11 patients), systemic JXG (4 patients), and RDD (3 patients).</p> </sec> <sec id="pbc24772-sec-0002" sec-type="section"> <title>Methods</title> <p>Patients treated with clofarabine for LCH, JXG, or RDD by Texas Children's Hospital physicians or collaborators between May 2011 and January 2013 were reviewed for response and toxicity.</p> </sec> <sec id="pbc24772-sec-0003" sec-type="section"> <title>Results</title> <p>Patients were treated with a median of three chemotherapeutic regimens prior to clofarabine. Clofarabine was typically administered at 25 mg/m<sup>2</sup>/day for 5 days. Cycles were administered every 28 days for a median of six cycles (range: 2–8 cycles). Seventeen of 18 patients are alive. All surviving patients showed demonstrable improvement after two to four cycles of therapy, with 11 (61%) complete responses, 4 (22%) partial responses, and 2 patients still receiving therapy. Five patients experienced disease recurrence, but three of these subsequently achieved complete remission. All patients with JXG and RDD had complete or partial response at conclusion of therapy. Side effects included neutropenia in all patients. Recurring but sporadic toxicities included prolonged neutropenia, severe vomiting, and bacterial infections.</p> </sec> <sec id="pbc24772-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Clofarabine has activity against LCH, JXG, and RDD in heavily pretreated patients, but prospective multi‐center trials are warranted to determine long‐term efficacy, optimal dosing, and late toxicity of clofarabine in this population. Pediatr Blood Cancer 2014;61:479–487. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>