A noninvasive tumor oxygenation imaging strategy using magnetic resonance imaging of endogenous blood and tissue water. Issue 2 (27th February 2013)

• Record Type: Journal Article
• Authors: Zhang, Zhongwei; Hallac, Rami R.; Peschke, Peter; Mason, Ralph P.
• Is Part Of: Magnetic resonance in medicine. Volume 71:Issue 2(2014:Feb.)
• Page Start: 561
• Page End: 569
• Publication Date: 2013-02-27
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.24691
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm24691-sec-0001" sec-type="section"> <title>Purpose</title> <p>To present a novel imaging strategy for noninvasive measurement of tumor oxygenation using MR imaging of endogenous blood and tissue water.</p> </sec> <sec id="mrm24691-sec-0002" sec-type="section"> <title>Theory and Methods</title> <p>The proposed approach for oxygen partial pressure (pO<sub>2</sub>) estimation is based on intravoxel incoherent motion diffusion MRI and the dependence of the blood <italic>R</italic><sub>2</sub> relaxation rate on the inter‐echo spacing measured using a multiple spin‐echo Carr‐Purcell‐Meiboom‐Gill sequence and weak‐field diffusion model. The accuracy of the approach was validated by comparison with <sup>19</sup>F MRI oximetry.</p> </sec> <sec id="mrm24691-sec-0003" sec-type="section"> <title>Results</title> <p>The results in eight rats at 4.7 T showed that tumors have longer <italic>T</italic><sub>1</sub> (1980 ± 186 ms) and <italic>T</italic><sub>2</sub> (59 ± 9 ms) relaxation times, heterogeneous blood volume fraction (0.23 ± 0.1), oxygen saturation level (<italic>Y</italic>) (0.53 ± 0.12), and pO<sub>2</sub> (36 ± 15 mmHg) distributions compared with normal muscle (<italic>T</italic><sub>1</sub> 1480 ± 86 ms, <italic>T</italic><sub>2</sub> 29 ± 2 ms, blood volume fraction 0.22 ± 0.03, <italic>Y</italic> 0.49 ± 0.06, and pO<sub>2</sub> 39 ± 5 mmHg). pO<sub>2</sub> estimates based on the novel <sup>1</sup>H approach were essentially identical with <sup>19</sup>F observations.</p> </sec> <sec id="mrm24691-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The study indicates that noninvasive measurement of tumor pO<sub>2</sub> using <sup>1</sup>H MRI derived multiparametric maps is feasible and could become a valuable tool to evaluate tumor hypoxia. Magn Reson Med 71:561–569, 2014. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>