Rapid measurement of arterial input function in mouse tail from projection phases. Issue 1 (14th February 2013)

• Record Type: Journal Article
• Authors: Moroz, Jennifer; Wong, Clayton L.; Yung, Andrew C.; Kozlowski, Piotr; Reinsberg, Stefan A.
• Is Part Of: Magnetic resonance in medicine. Volume 71:Issue 1(2014:Jan.)
• Page Start: 238
• Page End: 245
• Publication Date: 2013-02-14
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.24660
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm24660-sec-0001" sec-type="section"> <title>Purpose</title> <p>To measure the arterial input function (AIF) in a mouse tail at high temporal resolution with signal phase of MR projections.</p> </sec> <sec id="mrm24660-sec-0002" sec-type="section"> <title>Methods</title> <p>The technique involves the acquisition of one 2D image before injection, followed by a series of projections before, during, and after contrast injection. Differences in the signal phase, relative to the mean preinjection phase, were calculated and converted into a concentration of Gd.</p> </sec> <sec id="mrm24660-sec-0003" sec-type="section"> <title>Results</title> <p>An AIF with a temporal resolution of 100 ms was measured and verified with colorimetry (in a flow phantom) and mass spectrometry analysis (in vivo). The projection‐based AIF is expected to better represent the rapid contrast kinetics in the blood following injection, thus improving the accuracy of quantitative dynamic contrast‐enhanced‐MRI analysis. Colorimetry experiments confirmed that signal phase is preferred over magnitude for a precise determination of an AIF. In‐vivo experiments demonstrate the feasibility of our approach in mice.</p> </sec> <sec id="mrm24660-sec-0004" sec-type="section"> <title>Conclusion</title> <p>AIFs can be measured quickly and precisely using phase from projections. Phase data are sensitive to the flow velocity; but this sensitivity is significantly reduced when flow compensation was used. Magn Reson Med 71:238–245, 2014. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>