Volumetric B1+ Mapping of the Brain at 7T using DREAM. Issue 1 (14th February 2013)

• Record Type: Journal Article
• Authors: Nehrke, Kay; Versluis, Maarten J.; Webb, Andrew; Börnert, Peter
• Is Part Of: Magnetic resonance in medicine. Volume 71:Issue 1(2014:Jan.)
• Page Start: 246
• Page End: 256
• Publication Date: 2013-02-14
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.24667
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm24667-sec-0001" sec-type="section"> <title>Purpose</title> <p>To tailor and optimize the Dual Refocusing Echo Acquisition Mode (DREAM) approach for volumetric <italic>B</italic><sub>1</sub><sup>+</sup> mapping of the brain at 7T.</p> </sec> <sec id="mrm24667-sec-0002" sec-type="section"> <title>Theory and Methods</title> <p>A new DREAM echo timing scheme based on the virtual stimulated echo was derived to minimize potential effects of transverse relaxation. Furthermore, the DREAM <italic>B</italic><sub>1</sub><sup>+</sup> mapping performance was investigated in simulations and experimentally in phantoms and volunteers for volumetric applications, studying and optimizing the accuracy of the sequence with respect to saturation effects, slice profile imperfections, and <italic>T</italic><sub>1</sub> and <italic>T</italic><sub>2</sub> relaxation. Volumetric brain protocols were compiled for different isotropic resolutions (5–2.5 mm) and SENSE factors, and were studied in vivo for different RF drive modes (circular/linear polarization) and the application of dielectric pads.</p> </sec> <sec id="mrm24667-sec-0003" sec-type="section"> <title>Results</title> <p>Volumetric <italic>B</italic><sub>1</sub><sup>+</sup> maps with good SNR at 2.5 mm isotropic resolution were acquired in about 20 s or less. The specific absorption rate was well below the safety limits for all scans. Mild flow artefacts were observed in the large vessels. Moreover, a slight contrast in the ventricle was observed in the <italic>B</italic><sub>1</sub><sup>+</sup> maps, which could be attributed to <italic>T</italic><sub>1</sub> and <italic>T</italic><sub>2</sub> relaxation effects.</p> </sec> <sec id="mrm24667-sec-0004" sec-type="section"> <title>Conclusion</title> <p>DREAM enables safe, very fast, and robust volumetric <italic>B</italic><sub>1</sub><sup>+</sup> mapping of the brain at ultrahigh fields. <bold>Magn Reson Med 71:246–256, 2014. © 2013 Wiley Periodicals, Inc.</bold></p> </sec> </abstract>