Factors implicated in pathogenesis of urinary tract infections in neurogenic bladders: some revered, few forgotten, others ignored. Issue 1 (4th March 2013)

• Record Type: Journal Article
• Authors: Vasudeva, Pawan; Madersbacher, Helmut
• Is Part Of: Neurourology and urodynamics. Volume 33:Issue 1(2014:Jan.)
• Page Start: 95
• Page End: 100
• Publication Date: 2013-03-04
• Subjects: Urinary organs -- Periodicals; Urodynamics -- Periodicals; Urology -- Periodicals; 616.6
• DOI: 10.1002/nau.22378
• Languages: English
• ISSNs: 0733-2467

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="nau22378-sec-0001" sec-type="section"> <title>Aims</title> <p>To comprehensively review factors implicated in the pathogenesis of urinary tract infection in patients with neurogenic bladders, and to stimulate research, especially in the somewhat ignored and forgotten areas of this important clinical subject.</p> </sec> <sec id="nau22378-sec-0002" sec-type="section"> <title>Methods</title> <p>In addition to reviewing relevant articles on pubmed, some important articles from previous times which were not available online were also procured and reviewed.</p> </sec> <sec id="nau22378-sec-0003" sec-type="section"> <title>Results</title> <p>Intrinsic defence mechanisms including protective flora, anti‐adherence mechanisms, urothelial, and immunological responses to bacterial binding and the blood supply to the urinary bladder may be impaired in patients with neurogenic bladders. Further, bacterial washout mechanisms may be compromised as a result of inefficient voiding, reflux, and altered hydrokinetics. Finally, catheterization itself contributes to urinary tract infection in patients with neurogenic bladders.</p> </sec> <sec id="nau22378-sec-0004" sec-type="section"> <title>Conclusions</title> <p>In order to address the issue of urinary tract infection in patients with neurogenic bladders, multiple factors need to be looked into and corrected. Further research is required, especially in the area of compromised host defence mechanisms. An individualized approach, which attempts to optimize each factor is recommended. <italic>Neurourol. Urodynam. 33:95–100, 2014</italic>. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>