Reg3G gene expression in regenerating skeletal muscle and corresponding nerve. Issue 1 (5th December 2013)

• Record Type: Journal Article
• Authors: Klasan, Gordana Starcevic; Ivanac, Danijel; Erzen, Dubravka Jurisic; Picard, Anne; Takasawa, Shin; Peharec, Stanislav; Arbanas, Juraj; Girotto, Dean; Jerkovic, Romana
• Is Part Of: Muscle & nerve. Volume 49:Issue 1(2014:Jan.)
• Page Start: 61
• Page End: 68
• Publication Date: 2013-12-05
• Subjects: Neuromuscular diseases -- Periodicals; Muscles -- Periodicals; Nerves -- Periodicals; 616.74
• DOI: 10.1002/mus.23877
• Languages: English
• ISSNs: 0148-639X

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p> <italic>Introduction</italic>: The <italic>Reg</italic> genes play a major role in the regeneration of various tissues; however, no reports have been published regarding expression of the <italic>Reg3G</italic> gene in skeletal muscle. In this study we investigated the expression of the <italic>Reg3G</italic> gene in regeneration of rat skeletal muscle and injured nerves. <italic>Methods</italic>: We used 3 experimental models of muscle and nerve injury. RT‐PCR and Western blot analysis were performed for detection of Reg3G in regenerating muscle and nerve. <italic>Results</italic>: We found transcriptional activation of the <italic>Reg3G</italic> gene in the soleus and extensor digitorum longus muscles and in their corresponding nerves after both muscle and nerve injury in different time periods, respectively. <italic>Conclusions</italic>: The results suggest that the <italic>Reg3G</italic> gene plays a major role in communication between injured axons and muscle and may play a significant role in skeletal muscle and peripheral nerve regeneration. <italic>Muscle Nerve</italic><bold>49</bold>: 61–68, 2014</p> </abstract>